Permian’s 2025 schedule will feature trips to Plano (The Star in Frisco) and Amarillo Tascosa (Dick Bivins Stadium) in non-district action. The Panthers will play visitors with Odessa High, Midland Legacy, and Frenship in district. An interstate meeting with California’s San Bernardino Cajon will be hosted at Ratliff Stadium.
| DATE | OPPONENT | STADIUM | TIME |
| 08/30 | Plano | Away | 17-27 |
| 09/04 | El Paso Eastlake | Home | 27-12 |
| 09/12 | Abilene High | Away | 38-21 |
| 09/18 | Amarillo Tascosa | Away | 23-21 |
| 09/26 | San Bernardino (CA)++ | Home | 36-25 |
| 10/10 | Odessa High* | Away | 7:30 |
| 10/17 | San Angelo Central* | Home | 7:30 |
| 10/24 | Midland Legacy* | Away | 7:30 |
| 10/31 | Wolfforth Frenship* | Away | 7:30 |
| 11/07 | Midland High* | Home | 7:30 |
KEY: *District Game | ++Homecoming
